Madrid, EvaEvaMadridRojas, ValeriaValeriaRojasNicolás MezaReginald ReesCamila Micaela Escobar LiquitayJuan Víctor Ariel FrancoYanina SguasseroKatrina WilliamsTamara Pringsheim2025-08-252025-08-252022-05-0310.1002/14651858.cd0149652-s2.0-85129419721https://cris-uv-2.scimago.es/handle/123456789/5818Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. Primary To assess the comparative efficacy of atypical antipsychotics for irritability through network meta-analysis in children and adults with autism spectrum disorder (ASD). Secondary To assess the safety and efficacy of atypical antipsychotics as medications for core and non-core symptoms in children and adults with ASD.enacceso abiertoMedicinePharmacologyarticle