Enrique WernerBastian SaidPatricio GodoyXimena BesoainNelson CaroAlejandro MadridMontenegro, IvánIvánMontenegro2025-04-132025-04-132020-06-1010.3390/antibiotics90603172-s2.0-85088055384https://cris-uv-2.scimago.es/handle/123456789/2156WOS:000552458100001In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100–175 μg/mL and 100–200 μg/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound 9 caused damage and disintegration cell membrane of all Saprolegnia strains over the action of commercial controls.enacceso abiertoBiochemistryInfectious DiseasesMicrobiologyPharmacology And PharmacyPharmacologyPharmacology, Toxicology And Pharmaceuticsarticle