Saez, JuanJuanSaezJosé Luis VegaCamila GutiérrezMauro RojasJuan Güiza2025-08-252025-08-252023-01-0910.3389/fcell.2022.10943622-s2.0-85146848185https://cris-uv-2.scimago.es/handle/123456789/4874WOS:000921453700001Plasma membrane ionic channels selectively permeate potassium, sodium, calcium, and chloride ions. However, large-pore channels are permeable to ions and small molecules such as ATP and glutamate, among others. Large-pore channels are structures formed by several protein families with little or no evolutionary linkages including connexins (Cxs), pannexins (Panxs), innexin (Inxs), unnexins (Unxs), calcium homeostasis modulator (CALHMs), and Leucine-rich repeat-containing 8 (LRRC8) proteins. Large-pore channels are key players in inflammatory cell response, guiding the activation of inflammasomes, the release of pro-inflammatory cytokines such as interleukin-1 beta (IL-1ß), and the release of adenosine-5′-triphosphate (ATP), which is considered a danger signal. This review summarizes our current understanding of large-pore channels and their contribution to inflammation induced by microorganisms, virulence factors or their toxins.enacceso abiertoCell BiologyDevelopmental Biologyreview