Montenegro, IvánIvánMontenegroVillena, JuanJuanVillenaBeatriz EscobarJoan VillenaEnrique WernerPatrício GodoyYusser OlguínAlejandro Madrid2025-08-252025-08-252017-06-1010.3390/molecules220609682-s2.0-85021121802https://cris-uv-2.scimago.es/handle/123456789/3134WOS:000404642100113An efficient synthesis of a series of 4′-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by 1H-NMR, 13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4′-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.enacceso abiertoAnalytical ChemistryChemistry, OrganicChemistryDrug DiscoveryMedicineMolecular MedicineOrganic ChemistryPharmaceutical SciencePhysical And Theoretical Chemistryarticle