Hypothalamic gliosis as a potential mediator of improved glucose tolerance induced by time-restricted feeding in obese mice

Camila Astudillo-GuerreroDaniela FernandoisEmilie CaronVincent PrevotJoshua P. ThalerMauricio D. DorfmanCruz, GonzaloGonzaloCruz2026-02-252026-02-252025-09-0110.1152/ajpcell.00357.2025https://cris-uv-2.scimago.es/handle/123456789/8580 This study shows that time-restricted feeding (TRF) improves glucose tolerance in obese mice independently of weight loss. Surprisingly, this benefit is linked to increased hypothalamic gliosis, challenging the view that gliosis is solely detrimental in obesity. Although TRF elevates circulating β-hydroxybutyrate (BHB), peripheral and central BHB delivery fails to mimic TRF’s glycemic benefits or affect hypothalamic gliosis. These findings suggest gliosis may play a previously unrecognized role in mediating TRF’s metabolic benefits. Hypothalamic gliosis as a potential mediator of improved glucose tolerance induced by time-restricted feeding in obese micejournal-article