Montenegro, IvánIvánMontenegroVillena, JuanJuanVillenaOciel MuñozJoan VillenaEnrique WernerMarco MelladoIngrid RamírezNelson CaroSusana FloresAlejandro Madrid2025-08-252025-08-252018-06-0710.3390/molecules230613772-s2.0-85048308846https://cris-uv-2.scimago.es/handle/123456789/3037WOS:000435875400138To investigate the anti-Saprolegnia activities of chalconic compounds, nine dialkoxychalcones 2–10, along with their key building block 2′,4′-dihydroxychalcone 1, were evaluated for their potential oomycide activities against Saprolegnia australis strains. The synthesis afforded a series of O-alkylated derivatives with typical chalcone skeletons. Compounds 4–10 were reported for the first time. Interestingly, analogue 8 with the new scaffold demonstrated remarkable in vitro growth-inhibitory activities against Saprolegnia strains, displaying greater anti-oomycete potency than the standard drugs used in the assay, namely fluconazole and bronopol. In contrast, a dramatic loss of activity was observed for O-alkylated derivatives 2, 3, 6, and 7. These findings have highlighted the therapeutic potential of the natural compound 1 scaffold to be exploitable as a drug lead with specific activity against various Saprolegnia strains.enacceso abiertoAnalytical ChemistryChemistry, OrganicChemistryDrug DiscoveryMedicineMolecular MedicineOrganic ChemistryPharmaceutical SciencePhysical And Theoretical Chemistryarticle