Gerardo GilliganRené PanicoJerónimo LazosRosana MorelattoPaola BelardinelliMaria Ines CriscuoloNicolas BolesinaIgnacio Molina ÁvilaJuan Martin Pimentel SoláEmilce RivarolaMaria Jimena MorganteMaria Eugenia Ingrassia TonelliJavier GimenezPablo DorattiLaura Cecilia WernerAna Carolina Prado‐RibeiroThais Bianca BrandãoAljomar Jose Vechiato‐FilhoMaria Claudia CuzzullinCristina Saldivia‐SiracusaMarcio Ajudarte LopesMichelle AgostiniMario José RomañachAline Corrêa AbrahãoThamyres Campos FonsêcaEstela KaminagakuraAna Lia AnbinderKamilla Santos AlvesMaria Leticia de Almeida LançaSonia Sacsaquispe‐ContrerasKarem Rodriguez IbazettaRoberto Gerber‐MoraSaray Aranda RomoFrancisco Javier Tejeda NavaCordero, KarinaKarinaCorderoWilfredo Gonzalez‐ArriagadaRaiza ToroFelipe Martins SilveiraNatalia GonzalezPablo Agustin VargasAlan Roger Santos‐SilvaRonell Bologna‐MolinaMariana Villarroel‐DorregoBenjamin MartinezEduardo PiemonteMoreno, RicardoRicardoMoreno2025-04-142025-04-142023-10-2510.1111/odi.147782-s2.0-85174586825https://cris-uv-2.scimago.es/handle/123456789/2373WOS:001090920900001Abstract Objective To determine the frequency of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD), and the epidemiological profile and traditional risk factors in Latin America. Methods A retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential‐OSCC versus OSCC‐de novo (OSCC‐dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's t ‐test, and qualitative variables with chi‐square. Results In total, 2705 OSCC were included with a mean age of 62.8 years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC‐dn, while s‐OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD. Conclusions In Latin America, OSCC‐dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.enacceso abiertoDentistry, Oral Surgery And MedicineDentistryOtorhinolaryngologyarticle; early access