Cavieres, ÁlvaroÁlvaroCavieresMoya, PabloPabloMoyaBenjamín Pizarro-GalleguillosWaissbluthM. Leonor Bustamante2025-08-252025-08-252019-01-0110.4067/s0717-922720190004003942-s2.0-85079742710https://cris-uv-2.scimago.es/handle/123456789/3429Schizophrenia (SZ) is a highly heterogeneous clinical entity. It causes a severe disruption in quality of life, and it imposes a significant burden to society. Antipsychotics are the first line treatment, however up to a 30% of the patients will present resistance to treatment. Treatment resistant schizophrenia (TRS) could be a neurobiologically distinct disorder and not merely an extremely severe form of SZ. However, there is no consensus in the literature as to the definition of TRS. In the present work we review different definitions of TRS, mainly from clinical guidelines. Furthermore, we discuss therapeutic alternatives for TRS and suggest future perspectives regarding the identification of response predictors and understanding the neurobiology of TRS.esacceso abiertoNeurologyPsychiatry And Mental HealthSurgeryarticle