Madrid, EvaEvaMadridPérez, JavierJavierPérezWenru ShangHui XuMeixuan LiJunjie RenXinyu HuangJing LiXiaoqin WangQi WangYanfang MaJavier BracchiglioneLei JiangKehu YangLiang Yao2025-08-252025-08-252024-04-1810.1002/14651858.cd0158612-s2.0-85190950561https://cris-uv-2.scimago.es/handle/123456789/6319Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the comparative efficacy and safety of weight-loss drugs, provided in addition to lifestyle modification, for weight management in adults with overweight or obesity without diabetes. To obtain a ranking of pharmacological interventions for weight loss amongst the various available options through a network meta-analysis.enacceso abiertoMedicinePharmacologyarticle