Osvaldo AlvarezLatorre, RamónRamónLatorre2025-04-132025-04-132017-09-2010.1085/jgp.2017118392-s2.0-85030656082https://cris-uv-2.scimago.es/handle/123456789/2197WOS:000417978800005In 1943, David Goldman published a seminal paper in The Journal of General Physiology that reported a concise expression for the membrane current as a function of ion concentrations and voltage. This body of work was, and still is, the theoretical pillar used to interpret the relationship between a cell’s membrane potential and its external and/or internal ionic composition. Here, we describe from an historical perspective the theory underlying the constant-field equation and its application to membrane ion transport.enacceso abiertoPhysiologyreview