Reciprocal Relationship Between Calcium Signaling And Circadian Clocks: Implications For Calcium Homeostasis, Clock Function, And Therapeutics

Javier Cavieres-LepeEwer, JohnJohnEwer2025-12-082025-12-082021-05-1110.3389/fnmol.2021.6666732-s2.0-85107031020https://cris-uv-2.scimago.es/handle/123456789/7859WOS:000653440900001Graphical Abstract Reciprocal relationship between Ca 2+ signaling and the circadian clock. In Drosophila and mice, circadian clocks impose a daily rhythmicity to Ca 2+ signaling; and, conversely, Ca 2+ rhythms and signaling contribute to transmitting daily external signals to the clock TTFL. This bidirectional regulation is critical to the daily rhythmicity of many physiological and behavioral processes.enacceso abiertoCellular And Molecular NeuroscienceMolecular BiologyNeurosciencesReciprocal Relationship Between Calcium Signaling And Circadian Clocks: Implications For Calcium Homeostasis, Clock Function, And Therapeuticsreview