Ibacache, GermánGermánIbacacheJoaquin CavieresJavier E. Contreras‐Reyes2025-08-252025-08-252022-06-3010.1080/00949655.2022.20905642-s2.0-85133253661https://cris-uv-2.scimago.es/handle/123456789/4417WOS:000819537400001Expected Maximization (EM) algorithm is often used for estimation in semiparametric models with non-normal observations. However, the EM algorithm's main disadvantage is its slow convergence rate. In this paper, we propose the Laplace approximation to maximize the marginal likelihood, given a non-linear function assumed as a spline random effect for a skew-normal thin plate spline model. For this, we used automatic differentiation to get the derivatives and provide a numerical evaluation of the Hessian matrix. Comparative simulations and applications between the EM algorithm for thespatial dimension and Laplace approximation were carried out to illustrate the proposed method's performance. We show that the Laplace approximation is an efficient method, has flexibility to express log-likelihood in a semiparametric model and obtain a fast estimation process for non-normal models. In addition, a local influence analysis was carried out to evaluate the estimation sensitivity.enacceso restringidoApplied MathematicsComputer Science, Interdisciplinary ApplicationsModeling And SimulationStatistics And ProbabilityStatistics, Probability And Uncertaintyarticle; early access