Campos, CarolinaCarolinaCamposCavieres, ÁlvaroÁlvaroCavieresMoya, PabloPabloMoyaMoya, YannethYannethMoyaRocío MaldonadoRené González-VargasM. Leonor Bustamante2025-08-252025-08-252019-06-2510.1155/2019/56012492-s2.0-85068835154https://cris-uv-2.scimago.es/handle/123456789/3524WOS:000474543200001Alterations in neuroinflammatory processes have been suggested to contribute to the development of Schizophrenia (SZ); one component of the inflammatory system that has been linked to this disorder is interleukin-6 (IL-6). The minor allele of rs2228145, a functional polymorphism in the IL-6 receptor gene, has been associated to elevated IL-6 plasma levels and increased inflammatory activity, making it an interesting candidate to study as a possible factor underlying clinical heterogeneity in SZ. We studied a sample of 100 patients undergoing treatment with clozapine. Their symptoms were quantified by Brief Psychotic Rating Scale; those with the lowest scores (“remitted”) were compared with the highest (“clozapine treatment resistant”). We determined allelic frequencies for rs2228145 and IL-6 plasma levels. Our results do not support a role of IL-6 in response to treatment with clozapine. Further studies accounting for potential confounding factors are necessary.enacceso abiertoNeurologyPsychiatryPsychiatry And Mental Healtharticle