Prediction Of Peak-To-Peak Pressure Gradient In Patients With Aortic Coarctation Using Physics-Informed Neural Networks

Even after early repair of aortic coarctation (AoCo), life expectancy is reduced due to complications such as hypertension. Invasive diagnostic catheterization is used to evaluate peak-to-peak pressure gradients (PGpp) across the CoAo. Clinically significant PGpp are those greater than 20 mmHg under resting conditions, in which case the patient is referred for a second intervention to repair the CoAo. In this study, we demonstrate the feasibility of using Physics-Informed Neural Networks (PINNs) to predict PGpp in patients with AoCo non-invasively, based on images obtained from cardiac magnetic resonance imaging. We analyzed a group of 3 patients with CoAo under resting and pharmacological stress conditions. We were able to obtain PGpp values very close to the actual values obtained by diagnostic catheterization, with an absolute error and average percentage error of 0.57 mmHg and 8.29% for the resting condition, and 4.13 mmHg and 8.63% for the pharmacological stress condition. Our method also successfully identified the only patient who presented a clinically significant PGpp under resting conditions, with differences of less than 1 mmHg.